At the outset of the DREAMS project, adolescent girls and young women (AGYW) in sub-Saharan Africa accounted for nearly three-quarters of new HIV infections. This brief explores how DREAMS Innovation Challenge grantees enabled AGYW ages 15–24 to reduce their risk of HIV infection through holistic and innovative interventions that enhanced access to pre-exposure prophylaxis (PrEP). Oral PrEP is an antiretroviral self-administered pill taken once daily. Used in combination with safer sex practices, PrEP can reduce the risk of sexually acquired HIV in high-risk individuals by as much as 70 to 92% (Fonner et al. 2016; WHO 2015; UNAIDS 2017).
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