JSI RESOURCES: Journal article

Early Declines in Vaccine Type Pneumococcal Carriage in Children Less Than 5 Years Old After Introduction of 10-valent Pneumococcal Conjugate Vaccine in Mozambique

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Pneumococcal carriage is a precursor of invasive pneumococcal disease. Mozambique introduced 10-valent pneumococcal conjugate vaccine (PCV10) in April 2013, using a 3-dose schedule without a booster. They evaluated PCV10 impact on pneumococcal carriage and colonization density by HIV status. They conducted 2 cross-sectional surveys (pre and post PCV10 introduction) among children 6 weeks to 59 months old. Participants included HIV-infected children presenting for routine care at outpatient clinics and a random sample of HIV-uninfected children from the community.

Declines in vaccine-type carriage were observed in both HIV-uninfected and HIV-infected children after PCV10 introduction with an early signal of herd effect especially in HIV-infected children. Ongoing monitoring of increases in 19A carriage and disease is necessary.

Authors: Betuel Sigaugue, Benild Moiane, Sergio Massora, Fabiana Pimenta, Jennifer Verani, Helio Mucavele, Alberto Chaugue, Llorenc Quinto, Rita dos Santos, Maria da Gloria Carvalho, Cynthia Whitney, Fernanda Lessa

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